Lersivirine: a new NNRTI active across HIV-1 subtypes with a unique resistance profile
نویسندگان
چکیده
Purpose of the study Lersivirine (UK-453,051), a new potent NNRTI, displays novel binding with a unique in vitro resistance profile, and shows potential for use against transmitted NNRTI resistant virus and as a candidate for sequential NNRTI therapy. Further in vitro analyses have been performed to establish the breadth of activity and identify potential populations that might benefit from lersivirine therapy. Lersivirine activity against various HIV-1 subtypes and viruses with decreased susceptibility to etravirine (ETR) were characterised.
منابع مشابه
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2010